《无痛杀手》是一部有脚本的限定剧集,故事情节虚构,探讨了美国阿片类药物危机的起源和后果,重点讲述了肇事者、受害者和寻求真相者的故事,他们的生活因奥施康定的发明彻底改变了。《无痛杀手》对犯罪、问责制和屡屡令数十万美国人失败的制度进行了审视,改编自巴里·迈耶的《PAINKILLER》一书和帕特里克·拉登·基夫在《纽约客》杂志上发表的文章《The Family That Built an Empire of Pain》。监制阵容包括埃里克·纽曼、彼得·博格和亚历克斯·吉布尼,以及剧集主管/创剧人迈卡·费兹曼-布卢和诺亚·哈普斯特。主演阵容包括乌佐·阿杜巴、马修·布罗德里克、泰勒·克奇、迪纳·什瓦比和韦斯特·杜乔夫尼。
Returning series regulars include Sarah Jessica Parker, Cynthia Nixon, Kristin Davis, Sara Ramírez, Sarita Choudhury, Nicole Ari Parker, Karen Pittman, Mario Cantone, David Eigenberg, Evan Handler, Christopher Jackson, Niall Cunningham, Cathy Ang and Alexa Swinton. The series is executive produced by Michael Patrick King, John Melfi, Julie Rottenberg, Elisa Zuritsky, Sarah Jessica Parker, Kristin Davis and Cynthia Nixon. Writers included King, Samantha Irby, Susan Fales-Hill, Lucas Froehlich, Rachel Palmer, Julie Rottenberg and Elisa Zuritsky. Directors included King, Cynthia Nixon, Ry Russo-Young and Julie Rottenberg.
该剧改编自《火线警探》原作者Elmore Leonard的小说《City Primeval: High Noon In Detroit》,讲述8年后,已经离开肯塔基去往迈阿密的Raylan继续担任法警,也抚养着14岁女儿。然而佛罗里达高速路上的一次相遇让他去到了底特律,与一个反社会暴力狂“俄克拉荷马野人”狭路相逢,当地警方拿此人无能为力,而如今他想要再次逃脱法网。
DI Colette Cunningham's no nonsense approach to policing has earned her the respect of her Merseyside Police colleagues. She seems unflappable, until she gets a call from the Garda in Dublin after the body of a young woman is discovered.